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KMID : 0043320070300040402
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Archives of Pharmacal Research
2007 Volume.30 No. 4 p.402 ~ p.407
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Lignans from the Fruits of Cornus kousa Burg. and Their Cytotoxic Effects on Human Cancer Cell Lines
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Lee Dae-Young
Song Myoung-Chong
Yoo Ki-Hyun
Bang Myun-Ho
Chung In-Sik
Kim Sung-Hoon
Kim Dae-Keun
Kwon Byoung-Mog
Jeong Tae-Sook
Park Mi-Hyun
Baek Nam-In
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Abstract
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The fruits of Cornus kousa Burg. were extracted with 80% aqueous MeOH, and the concentrated extract partitioned with EtOAc, n-BuOH and H2O. Six lignans were isolated from the EtOAc fraction through repeated silica gel, ODS and Sephadex LH-20 column chromatographies. From the physico-chemical data, including NMR, MS and IR, the chemical structures of the compounds were determined to be (+)-pinoresinol (1), (-)-balanophonin (2), (+)-laricresinol (3), erythro-guaiacylglycerol-β-coniferyl aldehyde ether (4), threo-guaiacylglycerol-β-coniferyl aldehyde ether (5) and dihydrodehydrodiconiferyl alcohol (6), which were isolated for the first time from this plant. Most of these compounds showed cytotoxicity against human colon carcinoma (HCT-116) and human hepatocellular carcinoma (HepG2) cell lines in vitro, with IC50 values ranging from 19.1 to 71.3 μg/mL.
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KEYWORD
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Cornus kousa, Lignan, MTT assay, Cytotoxicity, Human colon carcinoma (HCT-116), Human hepatocellular carcinoma (HepG2)
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